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The number of all scientific works published in 2017 - 81, including: scientific articles - 58: abroad - 27, in local journals - 31. In the materials of the scientific conference - 23: on the international scale - 7, on the republican scale - 16.
The number of all scientific works published in 2018 - 98, including: scientific articles - 69: abroad - 22, in local journals - 47. In the materials of the scientific conference - 29: on the international scale - 11, on the republican scale - 18.
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The number of all scientific works published in 2019 is 72, including: scientific articles - 39: abroad - 18, in local journals - 21. In the materials of the scientific conference - 33: on the international scale - 14, on the republican scale - 19.
Batafsil
The number of all scientific works published in 2020 is 112, including: scientific articles - 79: abroad - 31, in local journals - 48. In the materials of the scientific conference - 33: on the international scale - 10, on the republican scale - 23.
Batafsil
The number of all scientific works published in 2021 is 125, including: scientific articles - 93: abroad - 42, in local journals - 51. In the materials of the scientific conference - 32: on the international scale - 21, on the republican scale - 11.
Batafsil
The number of all scientific works published in 2022 - 75, including: scientific articles - 38: abroad - 12, in local journals - 26. In the materials of the scientific conference - 37: on the international scale - 18, on the republican scale - 19.
Batafsil
Since 1987, within the framework of the State Program, the Institute has conducted research on the study of the state of the immune system in the practically healthy population of Uzbekistan. As a result of the conducted scientific expeditions, a map of normative indicators of immunity of the adult and children’s population was developed in the Republic of Uzbekistan.
In 1990-1991, the employees of the Institute, together with the employees of the Russian Institute of Immunology (Moscow), participated in studies of the immunity of accident liquidators in the 30 km zone of the Chernobyl NPP. As a result of long-term observations, data that objectively reflect the health and dynamics of accident liquidators, which are of great importance for practical health care, have been determined. These studies made a certain contribution to the development of clinical and radiation immunology.
As a result of the research conducted by the Institute of Immunology of the Academy of Sciences of the Republic of Uzbekistan and the scientists of the Republic of Karakalpakstan, the characteristic acute epidemiological situation in the Aral Sea region reflects the uniqueness of the complex of ecological, climatic and socio-hygienic factors in the life and activities of the population of this region. the widespread prevalence of digestive, reproductive and nervous system diseases indicates the presence of secondary immunodeficiency in the population.
Large-scale studies were conducted on the study of malignant tumor diseases of the population of the South Aral Sea region and Khorezm region. The HLA-A28 genotype, which plays an important role in the formation of stomach and colorectal cancer, was determined.
As part of a large-scale international research project within the framework of the ISAAC program, more than 3,000 children aged 7 to 15 years in all regions of Uzbekistan were examined for the presence of a tendency to develop bronchial asthma.
The Institute of Immunology of the Russian Academy of Sciences became one of the centers of the emergence of a new independent field of immunology – environmental immunology. The result of many years of population studies was that the presence of all HLA-antigens A, V, S, DR, DQ in the genome of the Uzbek population was confirmed. A1, A2, A9, A19, B5, B13, B21, B35 antigens were detected with a high frequency. Analysis of the genetic distance between Uzbeks and other populations and races, similarities in the frequencies of HLA genes between Uzbeks, the geographically close peoples of Central Asia (Turkmen, Kazakhs, Kyrgyz, Tajiks) and the European population and showed differences.
Uzbeks are distinguished by the diversity of HLA genes, in which almost all specific features of HLA and their haplotype combinations are found, which, most likely, reflects the large predominance of the European component of the Uzbek population as “mixed” – European-Mongoloid. makes
Prospects for these studies were associated with the transition to the molecular level of studying HLA genes. Employees of the Institute of Immunology of the Academy of Sciences of the Republic of Uzbekistan together with Stanford University (R.S. Wells, USA) and Oxford Institute of Molecular Medicine (W.J. Bodmer, Great Britain) conducted international expeditions to the Caucasus, Iran and Central Asia in 1998-2000. As a result, a unique DNA collection of 18 ethnic groups (more than 3000 samples) was collected. Using the PSR method, molecular typing of HLA and Y chromosome genes was carried out, which made it possible to include the HLA-A2 gene of the population of Uzbekistan in the International Register.
The transmission of genetic traits along the lines of Central Asian men and women is characterized by unique genetic diversity. This suggests that this region has long been a crossroads not only of pathways, but also of genes. For the first time, a map of the genetic diversity of Central Asian populations was created.
In 1996-2001, with participation in the global project “Human Genome” in the direction of “Diversity of the Human Genome”, the first large-scale medical genetic research began in the Central Asian region.