Based on the Decree of the President of the Republic of Uzbekistan dated July 5, 2018, No. PK-3838 “On Additional Measures for the Development of Fundamental and Applied Research, as well as Innovative Work in the Field of Immunology and Human Genomics” a branch of the institute was established in the Republic of Karakalpakstan without legal entity status.

Since 2018 and up to the present time, the branch has been headed by Doctor of Medical Sciences A.N. Kalandarova.

During the existence of the laboratory, the following issues have been studied:

Immunological profile (normative indicators) of the population in various regions of the Republic of Karakalpakstan;

Study of the prevalence of congenital immune disorders, the most common variants of clinical and immunological conditions in the Republic of Karakalpakstan.

The branch closely collaborates with medical universities and research institutes in Uzbekistan, as well as with institutions abroad.

Amina Nurullaevna Kalandarova – Doctor of Medical Sciences.

Research Areas: Fundamental and Clinical Immunology, Environmental Immunology, Obstetrics and Gynecology, Neonatology, and other directions.

BRIEF INFORMATION

about the head of the Nukus branch of the Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan, Doctor of Medical Sciences, Amina Nurullaevna Kalandarova:

Amina N. Kalandarova is known for her scientific research in the field of immunology and actively participates in national and international scientific conferences.

Amina N. Kalandarova has published over 100 scientific papers, including 3 monographs and 1 textbook.

Amina N. Kalandarova has been awarded the Order “Soglom avlod uchun” II degree and the title “Honored Worker of Healthcare of the Republic of Uzbekistan”.

Amina N. Kalandarova is known for her scientific research in the field of immunology and actively participates in national and international scientific conferences.

Amina N. Kalandarova has published over 100 scientific papers, including 3 monographs and 1 textbook.

Amina N. Kalandarova has been awarded the Order “Soglom avlod uchun” II degree and the title “Honored Worker of Healthcare of the Republic of Uzbekistan”.

EMPLOYEES OF THE LABORATORY

• Jiemuratova Gulparshin Koshkinbayevna – Doctor of Medical Sciences, Senior Researcher
• Kadirova Aygul Miirbekovna – Junior Researcher
• Jamalova Gozzal Allanazarovna – Laboratory Assistant

• Investigation of the cellular (Th1 and Th2) and humoral components of the immune system in various immunodeficient diseases (viral, bacterial, and fungal) in children and their mothers using molecular genetic methods.
• Monitoring the immune status of populations in different regions of Uzbekistan. Research on the impact of adverse environmental factors on the development of immunological deficiencies.
• Study of cellular mechanisms of immune response in immunodeficient conditions in experiments. Search for new methods of immunodiagnostics. Development of effective methods of immunocorrection and immunorehabilitation of immunodeficient conditions using new immunotropic drugs.

Research conducted under the State Programs for Scientific Activities of the Ministry of Innovative Development of the Republic of Uzbekistan:

In accordance with the research plan of the Nukus Branch of the Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan, with the number ALM – 202306161923 on the topic: “Development of regional characteristics, diagnostic and prognostic criteria for clinico-immunogenetic changes in some viral etiology diseases (acute bronchitis, pneumonia) after COVID-19 infection against the background of anemia in children living in the Aral Sea region” (2023-2026).

1. Monographs

Republican monographs and textbooks:

1. Kalandarova A.N., Aripova T.U., Musakhodjaeva D.A. Clinical and Immunogenetic Features in the Pathogenesis of Cervical Intraepithelial Neoplasia. // Monograph. Tashkent 2023, -147 p.

1. Articles (2020-2023)
2. In international publications:
3. Jiemuratova G.K., Mambetkarimov G.A., Turdymuratova K.O. Prevalence of allergic diseases in children in the Aral Sea region. // Implementation of Innovative Developments: Problems and Perspectives. Part 2. Collection of articles of the International Scientific and Practical Conference – Magnitogorsk, January 9, 2020. P.195-197
4. Jiemuratova G.K., Ahmedjanova Z.I., Danilova E.A., Urunova D.M., Karimov D.A. Macro- and microelements in the organism’s vital activity and their relationship with the immune system. // Journal of Theoretical and Clinical Medicine – Tashkent, No. 1, 2020. P.67-71
5. Jiemuratova G.K., Janabaeva G.U., Otekeeva S.S. Immunological mechanisms of skin and mucous membrane protection. // Scientific Journal “Bulletin of Science and Practice” Russia, Nizhnevartovsk No. 5, 2020. P.47-49
6. Jiemuratova G.K. Leukocyte formula as an indicator of children’s adaptation status in the Aral Sea region. // Journal of Theoretical and Clinical Medicine – Tashkent, No. 2, 2020. P.64-67
7. Musakhodjaeva D.A., Magzumova N.M., Tosheva I.B., Kalandarova A.N., Grigoryants K.E, Khakimova G.B., Ismoilova D.U. CYTOKINE PROFILE CHANGING IN WOMEN WITH CHORIOAMNIONITIS IN THE THIRD TRIMESTER OF PREGNANCY// Chin J IndHygOccup Dis, 2021: Vol. 39, с. 117-123 (№ 6). DOI: 10.5281/zenodo.5173727
8. MusakhodjaevaDiloram A., Aripova Tamara U., FayzullayevaNigoraYa., MuzafarovaSalima A., Kalandarova Amina N., AzizovaZukhra Sh., Grigoryants Karina E., KhakimovaGulshan B., AkhmedjanovaZulfiya I., RaufovAliher. Cytokine profile in physiologically occurring pregnancy// Chin J IndHygOccup Dis: Vol.39, pp. 390-395 (No.7).
9. Kalandarova A.N., Jiemuratova G.K., Kadyrova A.M. Immunological Aspects of COVID-19 in Women of Childbearing Age in the Aral Sea Region. // Bulletin of the South Kazakhstan Medical Academy No.2(96), 2022, pp. 144-147
10. Jiemuratova G.K., Danilova.E.A., Аkhmedjanova Z.I. Features of changes in some microelements in children of the Aral sea reglon. The  European science review, №5-6, 2022
11. Jiemuratova G.K., Kalandarova A.N., Kadyrova A.M. The influence of environmental factors on the nonspecific immunity of children living in the Aral Sea region. The  European science review, №5-6, 2022
12. Jiemuratova G.K., Ahmedjanova Z. I., Kalandarova A. N. Kadyrova A. M. The significance of a tumor marker in the screening examination of children living in unfavorable region //European Journal of Pharmaceutical and Medical Research (ejpmr), 2023, Vol 10 (5), Issue 5, -P. 514-516 www.ejpmr.com SJIF Impact Factor 6.222
13. Abdullaeva R.R., Jiemuratova G.K. Clinical – immunological aspects of allergic disease development in children with chronic adenoiditis //European Journal of Pharmaceutical and Medical Research (ejpmr), 2023, Vol 10 (6), Issue 6, -P. 514-516 www.ejpmr.com  SJIF Impact Factor 6.222
14. Jiemuratova G.K. The interplay between copper and cobalt in hematopoiesis and the Impact of their deficiency on anemia development //Журнал: Медицинская иммунология- СПб., 2023, Т. 25, № 3,C. 1073-1078 www.mimmun.ru (SCOPUS)  (14.00.00; №80)

1. In Republican publications
2. Jiemuratova G.K. The Relationship between the Quality of Drinking Water and the Non-Specific Adaptation Reaction of Children’s Organisms in the Aral Sea Region. // Journal of Theoretical and Clinical Medicine – Tashkent, No. 4, 2021. P.85-87.
3. Jiemuratova G.K., Mambetkarimov G.A., Kalandarova A.N., Kadyrova A.M. Adaptation-Adaptive Mechanisms of the Body to the Effects of Environmental Factors and Issues of Population Protection in the Aral Sea Region. // Journal New Day in Medicine, 9 (47) 2022 P.69-71
4. Esenbekova E.Zh., Zhiémuratova G.K., Zhaksylykova G.B. Features of the Immune Response in Children to the New Coronavirus Infection. // Journal New Day in Medicine, 9 (47) 2022 P.74-78
5. Jiemuratova G.K., Ahmedjanova Z.I., Kalandarova A.N., Mambetkarimov G.A. Influence of the Syndrome of Environmental Stress on the Physical Development of Children in the Aral Sea Region. // Journal of Theoretical and Clinical Medicine. – Tashkent, 2022 – No.4. – P.88-91.

5. Jiemuratova G.K., Ismailova A.A., Kalandarova A.N., Kadyrova A.M. Immunodeficiency state a modern perspective on the issue of
   “children with recurrent infections” //international scientific journal science and innovation. Issue dedicated to the 80^th anniversary of the academy of sciences of republic of Uzbekistan. September, 2023 Part 1 -P. 483-487(ISSN: 2181-3337; UIF-2022:8.2; SJIF 2023: 5.608)
6. Jiemuratova G.K., Kamalov Z.S., Ahmedjanova Z.I., Kalandarova A.N., Ahmedjanov R.I. Features of immune response in children with iron deficiency anemia who have recovered from coronavirus infection //international scientific journal science and innovation. Issue dedicated to the 80^th anniversary of the academy of sciences of republic of Uzbekistan. September 2023 Part 1 -P. 488-493. (ISSN: 2181-3337; UIF-2022:8.2; SJIF 2023: 5.608)
7. Aripova T.U., Jiemuratova G.K., Ahmedjanova Z.I., Ismailova A.A., Kalandarova A.A. Risk of Immunodeficiency Formation in Children Living in the Aral Sea Region. // Second Eurasian Forum on Diagnosis and Treatment of Rare Diseases, dedicated to the 80th anniversary of the Academy of Sciences of the Republic of Uzbekistan and the 70th anniversary of the birth of Academician Aripova T.U. – October 24-26, 2023. Journal of Theoretical and Clinical Medicine. – Tashkent, 2023 – No.4. P.63-66

Theses

1. Jiemuratova G.K. Influence of Nutrition on the Formation of Psychomotor Development in Early Childhood // Proceedings of the II International Scientific and Practical Conference “Borodin Readings”, dedicated to the 85th anniversary of Novosibirsk State Medical University – Novosibirsk. December 12, 2020. P. 221
2. Jiemuratova G.K. Oncological Diseases in Pediatric Practice // Scientific and Practical Medical Journal Children’s Medicine of the North-West (Детская медицина Северо-Запада). Saint Petersburg, 2021, volume 9, No. 1. P. 149
3. Jiemuratova G.K., Mambetkarimov G.A. Features of the Adaptation Status of Children in the Aral Sea Region // Scientific and Practical Medical Journal Children’s Medicine of the North-West (Детская медицина Северо-Запада). Saint Petersburg, 2021, volume 9, No. 1. P. 148
4. Danilova E.A., Osinskaya N.S., Jiemuratova G.K., Akhmedjanova Z.I., Khusniddinova S.Kh. Impact of the Aral sea region drinking water on the micronutrient status of children //International conference modern problems of nuclear technologies. November 23-25, 2021, p.210-211 Tashkent (Uzbekistan Institute of Nuclear Physics, Academy of Sciences of Uzbekistan)
5. Jiemuratova G.K., Ahmedjanova Z.I., Danilova E.A. Research of the content of macroelements in the hair of the Aral region //International conference modern problems of nuclear technologies. November 23-25, 2021, p.243 Tashkent (Uzbekistan Institute of Nuclear Physics, Academy of Sciences of Uzbekistan)
6. Jiémuratova G.K., Ahmedjanova Z.I. Content of Some Macro- and Microelements in Children with Cardiovascular Pathology in the Aral Sea Region // Cardiological Bulletin – a Scientific and Practical Reviewed Journal 2022, Moscow Vol. 17, p. 83, special issue (https://doi.org/10.17116/Cardiobulletin2022170225)
7. Kalandarova A.N., Jiémuratova G.K., Kadyrova A.M. Indicators of Some Immunological Parameters in Women of Childbearing Age Who Have Had COVID-19 in the Aral Sea Region // Scientific and Practical Medical Journal Children’s Medicine of the North-West (Детская медицина Северо-Запада) – Saint Petersburg, 2022, p. 238
8. Zhiémuratova G.K. Features of the Immune Response to the New Coronavirus Infection in Children with Iron-Deficiency Anemia // Scientific and Practical Medical Journal Children’s Medicine of the North-West (Детская медицина Северо-Запада) – Saint Petersburg, 2022. p. 200
9. Kalandarova A.N., Jiémuratova G.K., Kadyrova A.M. Hematological Indicators in Women with New Coronavirus Infection COVID-19 // Therapeutic Bulletin of Uzbekistan 2022. No. 3. p. 121 COLLECTED ABSTRACTS OF THE INTERNATIONAL FORUM OF THERAPISTS “CURRENT PROBLEMS OF INTERNAL ORGANS DISEASES” September 23-24, 2022, Tashkent
10. Jiémuratova G.K., Kalandarova A.N., Kadyrova A.M. Features of the Cardiovascular System Function in Young Children with Deficiency Anemia // Cardiological Bulletin – a Scientific and Practical Reviewed Journal 2022, Moscow (Russian Cardiology Bulletin, 2023 [www.cardioweb.ru]) Vol. 18, p. 150, special issue (https://doi.org/10.17116/Cardiobulletin2022170225) (SCOPUS)
11. Mambetkarimov G.A., Jiémuratova G.K., Tanirbergenova A.K. Assessment of the Functional State of the Cardiorespiratory System in Children Living in the Aral Sea Region // Cardiological Bulletin – a Scientific and Practical Reviewed Journal 2022, Moscow (Russian Cardiology Bulletin, 2023 [www.cardioweb.ru]) Vol. 18, p. 151, special issue [https://doi.org/10.17116/Cardiobulletin2022170225](https://doi.org/10.17116/Cardiobulletin2022170225) (SCOPUS)
12. Jiémuratova G.K., Oryngalievа N.D., Dzhumanazarova G.U. Assessment of the Prevalence of Deficiency, Excess Weight, and Obesity in Modern Schoolchildren // FORCIPE Scientific and Practical Journal for Students and Young Scientists. Special issue 1. National Congress with International Participation “Healthy Children – the Future of the Country” – St. Petersburg. June 15, 2023, Volume 6. p. 214
13. Jiémuratova G.K., Kalandarova A.N., Kadyrova A.M. Studies of Indicators of Nervous and Mental Development in Children under 6 years old // FORCIPE Scientific and Practical Journal for Students and Young Scientists. Special issue 1. National Congress with International Participation “Healthy Children – the Future of the Country” – St. Petersburg. June 15, 2023. Volume 6. p. 215
14. Jiémuratova G.K., Ismailova A.A., Kalandarova A.N., Kadyrova A.M. Immunological Markers in the Diagnosis of Primary Immunodeficiencies (PID) // International Scientific and Practical Internet Conference “Education, Science, Medicine”, dedicated to the 80th anniversary of the Academy of Sciences of the Republic of Uzbekistan. June 22, 2023. Journal of Theoretical and Clinical Medicine. – Tashkent, 2023 – No.3. p. 174
15. Ismailova A.A., Aripova T.U., Abdikhakimov A.N., Kalandarova A.N., Jiémuratova G.K., Kadyrova A.M., Habibullaev Sh.Z., Ibrahimova S.Z., Zhiémuratova G.K., Kalandarova A.N., Kadyrova A.M. Justification for the Development of a Clinical Protocol “Diagnosis and Treatment of Patients with Inborn Errors of Immunity “Primary Immunodeficiencies in the Republic of Uzbekistan” // International Scientific and Practical Internet Conference “Education, Science, Medicine”, dedicated to the 80th anniversary of the Academy of Sciences of the Republic of Uzbekistan. June 22, 2023. Journal of Theoretical and Clinical Medicine. – Tashkent, 2023 – No.3. p. 176
16. Jiémuratova G.K., Akhmedzhanova Z.I., Kamalov Z.S., Akhmedzhanov R.I. Analysis of Non-Specific Adaptive Reactions in Children Living in the Republic of Karakalpakstan. // Second Eurasian Forum on Diagnosis and Treatment of Rare Diseases, dedicated to the 80th anniversary of the Academy of Sciences of the Republic of Uzbekistan and the 70th anniversary of the birth of Academician Aripova T.U. – October 24-26, 2023. Journal of Theoretical and Clinical Medicine. – Tashkent, 2023 – No.4. p. 292-293
17. Methodological Recommendations and Information Letters
18. Methodological Recommendations
19. Jiémuratova G.M., Rakhimova G.N., Kalandarova A.N. Evaluation of the Effectiveness of Neonatal Screening for Congenital Hypothyroidism in the Republic of Karakalpakstan, Tashkent, 2021.
20. Jiemuratova G.K., Utepbergenova G.T. Actual Problems of Regional Pathology – Ecological Medicine. Nukus, 2021.
21. “Methodological Approaches to Studying the Adaptation Reactions of Children’s Organisms” by G.K. Zhiémuratova, Z.I. Akhmedzhanova, E.A. Danilova, G.A. Mambetkarimov (approved at the meeting of the Expert Council of the Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan on August 22, 2023, protocol No. DSc 3 u-t/001).
22. Methodological Recommendations on the topic: “Early Diagnosis of Disorders in the Neuro-Psychological Development of Preschool Children” (approved at the meeting of the Expert Council of the Institute of Immunology and Human Genomics of the Academy of Sciences of the Republic of Uzbekistan on August 22, 2023, protocol No. DSc 3 u-t/002)..

The laboratory closely collaborates with medical universities and research institutes in Uzbekistan, as well as institutions abroad, both near and far.

For many years of fruitful work, professional mastery, and high personal achievements in the field of healthcare, science, and training of highly qualified personnel, as well as effective implementation of modern medical technologies to improve the efficiency and quality of medical care for the population, Kalandarova A.N. was awarded:

– In 2008, the Order of “Soglom avlod uchun” II degree.

– In 2016, the title “Honored Worker of Healthcare of the Republic of Uzbekistan” was conferred upon her.