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Andijan branch of the intitute of immunology and human genomics of the Academy of the Republic of Uzbekistan

The laboratory’s research is focused on studying the role of excessive pro-inflammatory immune reactions in the early stages of miscarriage, the role of protease inhibitors, sex hormones, alarmins – early warning signals for the immune system and DNA methylation as an epigenetic factor in the mechanisms of development of excessive immune reactions in the early stages of miscarriage.

According to the decree of the President of the Republic of Uzbekistan Sh. M. Mirziyoyev, the Andijan branch of the Institute of Immunology and Human Genomics was opened in 2018. From 2018 to 2021, the laboratory was headed by Ph.D., associate professor D.Usmanova. From 2021 to 2023, the laboratory was headed by PhD, associate professor O. Egamberdiev. From 2023 to the present – headed by Doctor of Medical Sciences, professor V.A. Aleynik. 4 candidate’s theses were prepared and defended in the laboratory.

During the existence of the laboratory, the following problems were studied:

– the effect of hemalin in the treatment of viral infections;

– the influence of excessive pro-inflammatory immune reactions in the early stages of miscarriage;

– changes in cellular immunity and cytokines in excessive pro-inflammatory immune reactions in the early stages of miscarriage;

– the role of protease inhibitors in the mechanisms of excessive proinflammatory immune reactions in the early stages of miscarriage.

– the role of sexual activity in the mechanisms of excessive proinflammatory immune reactions in the early stages of miscarriage.

The laboratory works in close cooperation with the Andijan State Medical Institute.

Aleynik Vladimir Alekseevich – Doctor of Medical Sciences, Professor

Area of research: physiology and pathology of the gastrointestinal tract, fundamental and clinical immunology, epigenetics.

V.A. Aleynik has published more than 485 scientific works, including 2 monographs and 9 textbooks, as well as 9 patents issued by the Intellectual Property Agency of the Republic of Uzbekistan. 5 teaching aids have also been published. Under his leadership, 9 highly qualified specialists were trained, 2 of whom are doctors of science, and 7 are candidates of science. V.A. Aleynik was the first to prove the influence of the physicochemical interaction of nutrients on the disintegration of proteins, fats and carbohydrates in the upper gastrointestinal tract. In addition, he substantiated the influence of changes in the disintegration of nutrients on the formation of diseases of the stomach and duodenum. He argued the role of sterile inflammation in the occurrence of excessive pro-inflammatory immune reactions in women in the early stages of miscarriage. Based on the research results, the proposed teaching aids are widely used in practical medicine. Currently, scientific research by V.A. Aleinica include fundamental and clinical immunology, epigenetics. Physiology and pathology of the gastrointestinal tract, ophthalmology, surgery and other areas.

Aleynik Vladimir Alekseevich – Doctor of Medical Sciences, Professor

Juraev Boburbek Mukumjon ugli –  Junior researcher

Khalilova Gulnigor Abdumutalipovna – laboratory assistant

Sultanova Alfiya Khakimbekovna – laboratory assistant

Studying the role of protease inhibitors and sex hormones in excessive pro-inflammatory immune reactions in the early stages of miscarriage.

Studying the role of alarmins – early warning signals for the immune system and DNA methylation, as an epigenetic factor in the mechanisms of development of excessive pro-inflammatory immune reactions in the early stages of miscarriage.

Study of changes in immunological parameters of tears in various eye diseases among children and adolescents with tuberculosis.

Study of changes in immunological parameters in the composition of wound secretions from patients with long-healing wounds.

Study of changes in immunological parameters in the composition of wound secretions of patients with deep and superficial burns.

  1. Research conducted within the framework of budget topics financed by the State Committee for Science and Technology of the Republic of Uzbekistan:

SSV-F-037: “Study of the role of proteases and protease-activated liver receptors in the pathogenetic mechanisms of dysfunction of the digestive glands.” (2017-2020). Fundamental project

 

 

  1. Research carried out within the framework of State programs for scientific activities of the Ministry of Innovative Development of the Republic of Uzbekistan:

 

PZ-20170928646 “Development of a method for preventing miscarriage by inducing immune tolerance in women to husband’s antigens” (2018-2020) Applied project

 

  1. Research carried out at the expense of the Academy of Sciences of the Republic of Uzbekistan

“Studying the role of protease inhibitors and sex hormones in excessive pro-inflammatory immune reactions in the early stages of miscarriage” (2023-2025).

  1. Monographs

 

  1. Алейник В.А., Бабич С.М., Негматшаева Х.Н., Мухитдинова К.О. Чрезмерные провоспалительные иммунные реакции при невынашивании в ранние сроки беременности // Монография. Андижан. 2023, 187 с.

 

 

B.Patents

 

  1. № IAP 06857 М. А. Жураева, Алейник В.А., Бабич С.М. Способ лечения атрофического гастрита при хронических заболеваниях печени различной этиологии // Агенство по интеллектуаьной собственности РУз, от 31.03.2022 г
  2. № IAP 07048 В.А. Алейник, С.М. Бабич, К.О. Мухитдинова, Х.Н. Негматшаева, С. Р. Ибрагимова, С. М. Шокитова.  Лечение улиностатином иммунологических нарушений спермы // Агенство по интеллектуаьной собственности РУз, от 28.08.2022 г.

 

 

 

  1. D. Articles (2023-2024)

 

  1. In foreign publications:

 

  1. Shokirova S. M., Aleinik V.A., Ibragimova S.R., Yuldasheva A.S.. Influence Of Polycistronic of The Ovarian in Women with The Combined Presence of Infertility and Obesity on Changes in Insulin and Sex Hormones //Journal of Survey in Fisheries Sciences. – 2023. – Т. 10. – №. 2S. – С. 2804-2809.
  2. Алейник В. А., Бабич С. М., Концепция ферментативной дезинтеграции питательных веществ в верхнем отделе желудочно- кишечного тракта // Экспериментальная и клиническая гастроэнтерология. – – Т.  217. – №  9. –  С. 56-67.
  3. Azizov D. T., Mirzaev K. K., Aleynik V. A., Babich S. M., Changes in Local and Systemic Immune Factors in Patients with Purulent Wounds  // American Journal of Medicine and Medical Sciences. – 2023. – Т. 13. – № 12.- P. 1867-1869.

 

  1. In Republican publications:

 

  1. Маматхужаева Г.Н., Икрамов А.Ф., Алейник В.А. Иммунологические показатели слезы при блефаритах у детей и подростков больных туберкулёзом. //Медицинский журнал Узбекистана. -2023.- №4.-С. 12-15.
  2. Маматхужаева Г.Н., Икрамов А.Ф., Алейник В.А. Изменение иммунологических показателей слезы при хронических коньюнктивитах у детей и подростков больных туберкулёзом. //Журнал теоретической и клинической медицины. -2023. – №6.-С.82-87.
  3.   Алейник В.А., Мухитдинова К.О., Бабич С.М., Негматшаева Х.Н., Юлдашева А.С., Джураев Б.М., Эгамбердиев О. Изменение иммунологических показателей у женщин на ранних беременных, перенесших выкидыши при половых инфекциях // Новый день в медицине.  – 2023. – Т. 53. – №. 3. – С. 32-37.
  4. Алейник В.А., Мухитдинова К.О., Бабич С.М., Негматшаева Х.Н., Юлдашева А.С., Джураев Б.М. Изменение иммунологических показателей при наличии и отсутствии генитальных инфекций у женщин на ранних сроках беременности // Вестник врача. – 2023. – Т. 109. – №. 1. – С. 7-12. 
  5. Muxitdinova K.O., Aleynik V.A., Babich S.M., Negmatshaeva H.N., Yuldasheva A.S., Juraev B.M. Ayollarda erta homiladorlik davrida immunologik ko’rsatkichlar va proteaza ingibitorlarini o’zgarishi // Журнал теоретической и клинической медицины.  – 2023. – №. 2. – С. 71-74.
  6. Касимова Д.С., Алейник В.А., Бабич С.М., Хамракулов Ш.Х. Влияние взаимодействия между крахмалом и казеином в составе крахмально-казеиновых субстратов на изменение перевариваемости крахмала// Журнал Проблемы биологии и медицины. – 2023. – Т. 142. – №. 1. – С. 160-164.
  7. Касимова Д.С., Алейник В.А., Бабич С.М., Хамракулов Ш.Х. Изменение перевариваемости казеина при взаимодействии между крахмалом и казеином в составе крахмально-казеиновых субстратов // Проблемы биологии и медицины. – 2023. – Т. 142. – №. 1. – С. 165-168.
  8. Касимова Д.С., Алейник В.А., Бабич С.М., Хамракулов Ш.Х. Факторы влияния на изменение перевариваемости белков при взаимодействии их с крахмалом в составе крахмально-белковых субстратов// Журнал Вестник врача. – Т. 112. – №. 4. – С. 28-33.
  9. Мухитдинова К.О., Алейник В.А., Бабич С.М., Негматшаева Х.Н., Юлдашева А.С., Джураев Б.М. Изменения половых гормонов у женщин на ранних сроках беременности при отсутствии чрезмерной иммунной реакции // Новый день в медицине.  – 2024. – Т. 64. – №. 2. Февраль – С. 245-251.
  10. Алейник В.А., Мухитдинова К.О., Бабич С.М., Негматшаева Х.Н., Джураев Б.М. Влияние Контрикала и Клексана на динамику иммунологических показателей у женщин на раннем этапе беременности при наличии генитальных инфекций // Медицинский журнал Узбекистана.  – 2024. – Т. 64. – №. 1. – С. 35-44.
  11. Маматхужаева Г.Н., Икрамов А.Ф., Алейник В.А. Изменение показателей ингибиторов протеаз при применении иммуномодуляторов в лечении хронических блефаритов у детей и подростков больных туберкулёзом // Медицинский журнал Узбекистана.  – 2024. – Т. 64. – №. 1. – С. 89-94.
  12. Маматхужаева Г.Н., Икрамов А.Ф., Алейник В.А. Особенности иммунологических характеристик слезы при эписклеритах у детей и подростков больных туберкулёзом  // Медицинский журнал Узбекистана.  – 2024. – Т. 64. – №. 1. – С. 89-94.

The laboratory works in close cooperation with the Andijan State Medical Institute.